期刊论文详细信息
Applied Sciences | |
A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry | |
William C. Shearouse1  Maxwell Z. Shumba1  | |
[1] University of Cincinnati, Cincinnati, OH 45221-0172, USA; | |
关键词: Gewald; solvent-free; ball milling; green chemistry; multicomponent reaction; | |
DOI : 10.3390/app4020171 | |
来源: mdpi | |
【 摘 要 】
Herein, we report on the solvent-free synthesis of 2-aminothiophenes via the Gewald reaction. Utilizing high speed ball milling conditions, we discovered the Gewald reaction can be catalytic in base, and conducted under aerobic conditions. Using thermal heat in tandem with the mixer/mill significantly increases the rate of reaction.
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190027253ZK.pdf | 244KB | download |