Microarray-Based Gene Expression Profiling to Elucidate Effectiveness of Fermented Codonopsis lanceolata in Mice

International Journal of Molecular Sciences

Woon Yong Choi¹  Ji Seon Kim¹  Sung Jin Park²  Choong Je Ma¹ 

[1] Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, Korea; E-Mails:;Department of Tourism Food Service Cuisine, Hallym Polytechnic University, Gangwon 200-711, Korea; E-Mail:

关键词: fermented Codonopsis lanceolata;    microarray;    gene expression;    obesity;   

DOI  :  10.3390/ijms15045907

来源: mdpi

【 摘 要 】

In this study, the effect of Codonopsis lanceolata fermented by lactic acid on controlling gene expression levels related to obesity was observed in an oligonucleotide chip microarray. Among 8170 genes, 393 genes were up regulated and 760 genes were down regulated in feeding the fermented C. lanceolata (FCL). Another 374 genes were up regulated and 527 genes down regulated without feeding the sample. The genes were not affected by the FCL sample. It was interesting that among those genes, Chytochrome P450, Dmbt1, LOC76487, and thyroid hormones, etc., were mostly up or down regulated. These genes are more related to lipid synthesis. We could conclude that the FCL possibly controlled the gene expression levels related to lipid synthesis, which resulted in reducing obesity. However, more detailed protein expression experiments should be carried out.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland