Granulocyte Colony-Stimulating Factor in the Treatment of Acute Radiation Syndrome: A Concise Review

Molecules

Michal Hofer¹  Milan Pospíšil²  Denisa Komůrková² 

[1] Department of Molecular Cytology and Cytometry, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, Brno CZ-612 65, Czech Republic;

关键词: granulocyte colony-stimulating factor;    radiation accidents;    acute radiation syndrome;    radiation-induced myelosuppression;   

DOI  :  10.3390/molecules19044770

来源: mdpi

【 摘 要 】

This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.