期刊论文详细信息
International Journal of Molecular Sciences
LIM Mineralization Protein-1 Inhibits the Malignant Phenotypes of Human Osteosarcoma Cells
Huiwen Liu3  Lu Huang1  Zhongzu Zhang3  Zhanming Zhang2  Zhiming Yu3  Xiang Chen3  Zhuo Chen3  Yongping Zen3  Dong Yang3  Zhimin Han3  Yong Shu3  Min Dai3 
[1] Department of Children Health and Care, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, China; E-Mail:;Department of Oncology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China; E-Mail:;Department of Orthopedics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China; E-Mails:
关键词: LMP-1;    osteosarcoma;    tumor suppressor gene;    Runx2;    BMP-2;   
DOI  :  10.3390/ijms15047037
来源: mdpi
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【 摘 要 】

Osteosarcoma (OS), also known as osteogenic sarcoma, is the most common primary malignancy of bone tumor in children and adolescents. However, its underlying molecular pathogenesis is still only vaguely understood. Recently, LIM mineralization protein-1 (LMP-1) was reported to be an essential positive regulator of osteoblast differentiation. In the present study, we found that the expression of LMP-1 is downregulated in OS tissues compared with adjacent normal tissues. Moreover, we restored the expression of LMP-1 through a recombinant adenovirus. Overexpression of LMP-1 inhibited cell proliferation and invasion, arrested cell cycle progression, and induced apoptosis in vitro. Finally, ectopic LMP-1 expression suppressed the expression of Runx2 and BMP-2 in OS cells. These data demonstrate that LMP-1 is an essential tumor suppressor in the OS pathological process, which will provide a new opportunity for discovering and identifying novel effective treatment strategies.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland

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