Studies of Tumor Suppressor Genes via Chromosome Engineering

Cancers

Hiroyuki Kugoh²  Takahito Ohira²  Mitsuo Oshimura¹ 

[1] Chromosome Engineering Research Center (CERC), Tottori University, Yonago, Tottori 683-8503, Japan;Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan;

关键词: telomerase;    TERT;    tumor suppressor gene;    PITX1;    melanoma;    chromosome engineering;   

DOI  :  10.3390/cancers8010004

来源: mdpi

【 摘 要 】

The development and progression of malignant tumors likely result from consecutive accumulation of genetic alterations, including dysfunctional tumor suppressor genes. However, the signaling mechanisms that underlie the development of tumors have not yet been completely elucidated. Discovery of novel tumor-related genes plays a crucial role in our understanding of the development and progression of malignant tumors. Chromosome engineering technology based on microcell-mediated chromosome transfer (MMCT) is an effective approach for identification of tumor suppressor genes. The studies have revealed at least five tumor suppression effects. The discovery of novel tumor suppressor genes provide greater understanding of the complex signaling pathways that underlie the development and progression of malignant tumors. These advances are being exploited to develop targeted drugs and new biological therapies for cancer.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.