Design, Synthesis and Bioactivity of N-Glycosyl-N'-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives

International Journal of Molecular Sciences

Zining Cui¹  Hang Su²  Jiazhen Jiang²  Xinling Yang² 

[1] Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China;Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China; E-Mails:

关键词: glycosylhydrazide;    synthesis;    tautomer;    antifungal activity;    antitumor activity;   

DOI  :  10.3390/ijms15046741

来源: mdpi

【 摘 要 】

Condensation products of 5-substituted phenyl-2-furoyl hydrazide with different monosaccharides d-glucose, d-galactose,d-mannose, d-fucose and d-arabinose were prepared. The anomerization and cyclic-acyclic isomers were investigated by ¹H NMR spectroscopy. The results showed that, except for the d-glucose derivatives, which were in the presence of β-anomeric forms, all derivatives were in an acyclic Schiff base form. Their antifungal and antitumor activities were studied. The bioassay results indicated that some title compounds showed superior effects over the commercial positive controls.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland