Marine Drugs | |
Design, Synthesis and Biological Evaluation of Tasiamide Analogues as Tumor Inhibitors | |
Wei Zhang1  Tiantian Sun1  Zhenhua Ma1  | |
[1] Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China; | |
关键词: tasiamide; analogues; synthesis; cytotoxicity; marine peptide; | |
DOI : 10.3390/md12042308 | |
来源: mdpi | |
【 摘 要 】
Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190026527ZK.pdf | 1041KB | download |