Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)

Molecules

Ruofeng Shang²  Jianping Liang²  Yunpeng Yi²  Yu Liu²  Jiatu Wang¹ 

[1] Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China;Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China; E-Mails:

关键词: platensimycin;    platencin;    drug resistance;    antibacterial activities;    synthesis;    analogues;   

DOI  :  10.3390/molecules200916127

来源: mdpi

【 摘 要 】

Platensimycin and platencin were successively discovered from the strain Streptomyces platensis through systematic screening. These natural products have been defined as promising agents for fighting multidrug resistance in bacteria by targeting type II fatty acid synthesis with slightly different mechanisms. Bioactivity studies have shown that platensimycin and platencin offer great potential to inhibit many resistant bacteria with no cross-resistance or toxicity observed in vivo. This review summarizes the general information on platensimycin and platencin, including antibacterial and self-resistant mechanisms. Furthermore, the total synthesis pathways of platensimycin and platencin and their analogues from recent studies are presented.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.