Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility

International Journal of Molecular Sciences

Norihisa Saeki¹  Hiromi Sakamoto² 

[1] Division of Genetics, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan;

关键词: gastric cancer;    mucin 1;    Helicobacter pylori;    genome-wide association study;    single nucleotide polymorphism;    cancer susceptibility gene;   

DOI  :  10.3390/ijms15057958

来源: mdpi

【 摘 要 】

Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited. Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein. MUC1 has been known as an oncogene with an anti-apoptotic function in cancer cells; however, in normal gastric mucosa, it is anticipated that the mucin 1 protein has a role in protecting gastric epithelial cells from a variety of external insults which cause inflammation and carcinogenesis. HP infection is the most definite insult leading to GC, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland