Mouse Models of Gastric Cancer

Cancers

Yoku Hayakawa²  James G. Fox¹  Tamas Gonda²  Daniel L. Worthley²  Sureshkumar Muthupalani¹ 

[1] Division of Comparative Medicine, MIT, Cambridge, MA 02139, USA;Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY 10032, USA

关键词: gastric cancer;    mouse model;    metaplasia;    Helicobacter felis;    Helicobacter pylori;    INS-GAS mice;   

DOI  :  10.3390/cancers5010092

来源: mdpi

【 摘 要 】

Animal models have greatly enriched our understanding of the molecular mechanisms of numerous types of cancers. Gastric cancer is one of the most common cancers worldwide, with a poor prognosis and high incidence of drug-resistance. However, most inbred strains of mice have proven resistant to gastric carcinogenesis. To establish useful models which mimic human gastric cancer phenotypes, investigators have utilized animals infected with Helicobacter species and treated with carcinogens. In addition, by exploiting genetic engineering, a variety of transgenic and knockout mouse models of gastric cancer have emerged, such as INS-GAS mice and TFF1 knockout mice. Investigators have used the combination of carcinogens and gene alteration to accelerate gastric cancer development, but rarely do mouse models show an aggressive and metastatic gastric cancer phenotype that could be relevant to preclinical studies, which may require more specific targeting of gastric progenitor cells. Here, we review current gastric carcinogenesis mouse models and provide our future perspectives on this field.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.