Inhibitory Effects of Palmultang on Inflammatory Mediator Production Related to Suppression of NF-κB and MAPK Pathways and Induction of HO-1 Expression in Macrophages

International Journal of Molecular Sciences

You-Chang Oh¹  Yun Hee Jeong¹  Won-Kyung Cho²  Min-Jung Gu² 

[1] Korean Medicine (KM)-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, 461-24, Jeonmin-dong, Yuseong, Daejeon 305-811, Korea;

关键词: palmultang;    inducible nitric oxide synthase;    heme oxygenase-1;    nuclear factor-kappaB;    mitogen-activated protein kinase;   

DOI  :  10.3390/ijms15058443

来源: mdpi

【 摘 要 】

Palmultang (PM) is an herbal decoction that has been used to treat anorexia, anemia, general prostration, and weakness due to chronic illness since medieval times in Korea, China, and Japan. The present study focused on the inhibitory effects of PM on the production of inflammatory factors and on the activation of mechanisms in murine macrophages. PM suppressed the expression of nitric oxide (NO), inflammatory cytokines and inflammatory proteins by inhibiting nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signaling pathways and by inducing heme oxygenase (HO)-1 expression. Collectively, our results explain the anti-inflammatory effect and inhibitory mechanism of PM in macrophages stimulated with lipopolysaccharide (LPS).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland