Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism

International Journal of Molecular Sciences

Yuanyuan Zhang³  Li Wang¹  Soumyadeep Dey³  Mawadda Alnaeeli²  Sukanya Suresh³  Heather Rogers³  Ruifeng Teng⁴ 

[1] Faculty of Health Sciences, University of Macau, Macau SAR, China; E-Mail:;Department of Biological Sciences, Ohio University, Zanesville, OH 43701, USA; E-Mail:;Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA; E-Mails:;Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA; E-Mail:

关键词: erythropoietin;    erythropoietin receptor;    signal transduction;    stress response;    wound healing;    endothelial;    brain;    cardiovascular;    inflammation;    metabolism;    obesity;   

DOI  :  10.3390/ijms150610296

来源: mdpi

【 摘 要 】

Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress. The cloning and production of recombinant human EPO has led to its clinical use in patients with anemia for two and half decades and has facilitated studies of EPO action. Reports of animal and cell models of ischemic stress in vitro and injury suggest potential EPO benefit beyond red blood cell production including vascular endothelial response to increase nitric oxide production, which facilitates oxygen delivery to brain, heart and other non-hematopoietic tissues. This review discusses these and other reports of EPO action beyond red blood cell production, including EPO response affecting metabolism and obesity in animal models. Observations of EPO activity in cell and animal model systems, including mice with tissue specific deletion of EPO receptor (EpoR), suggest the potential for EPO response in metabolism and disease.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.