Nutrients | |
Is Omega-3 Fatty Acids Enriched Nutrition Support Safe for Critical Ill Patients? A Systematic Review and Meta-Analysis | |
Wei Chen1  Hua Jiang1  Zhi-Yuan Zhou2  Ye-Xuan Tao2  Bin Cai2  Jie Liu2  Hao Yang2  Charles Damien Lu2  | |
[1] Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Beijing 100730, China; E-Mail:;Department of Computational Mathematics and Bio-statistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu 610101, China; E-Mails: | |
关键词: omega-3 fatty acids; severe illness; parenteral nutrition; enteral nutrition; meta-analysis; | |
DOI : 10.3390/nu6062148 | |
来源: mdpi | |
【 摘 要 】
Objective: To systematically review the effects of omega-3 poly unsaturated fatty acids (FA) enriched nutrition support on the mortality of critically illness patients. Methods: Databases of Medline, ISI, Cochrane Library, and Chinese Biomedicine Database were searched and randomized controlled trials (RCTs) were identified. We enrolled RCTs that compared fish oil enriched nutrition support and standard nutrition support. Major outcome is mortality. Methodological quality assessment was conducted based on Modified Jadad’s score scale. For control heterogeneity, we developed a method that integrated I2 test, nutritional support route subgroup analysis and clinical condition of severity. RevMan 5.0 software (The Nordic Cochrane Centre, Copenhagen, Denmark) was used for meta-analysis. Results: Twelve trials involving 1208 patients that met all the inclusion criteria. Heterogeneity existed between the trials. A random model was used, there was no significant effect on mortality RR, 0.82, 95% confidence interval (CI) (0.62, 1.09),
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190025293ZK.pdf | 1018KB | download |