Nanomaterials | |
Assessment of the Aerosol Generation and Toxicity of Carbon Nanotubes | |
Patrick T. O’Shaughnessy1  Andrea Adamcakova-Dodd2  Ralph Altmaier2  | |
[1] The University of Iowa, Department of Occupational and Environmental Health, 100 CPHB S320, Iowa City, IA 52242, USA; | |
关键词: carbon nanotubes; aerosol generation; pulmonary response; inhalation; toxicity; | |
DOI : 10.3390/nano4020439 | |
来源: mdpi | |
【 摘 要 】
Current interest in the pulmonary toxicity of carbon nanotubes (CNTs) has resulted in a need for an aerosol generation system that is capable of consistently producing a CNT aerosol at a desired concentration level. This two-part study was designed to: (1) assess the properties of a commercially-available aerosol generator when producing an aerosol from a purchased powder supply of double-walled carbon nanotubes (DWCNTs); and (2) assess the pulmonary sub-acute toxicity of DWCNTs in a murine model during a 5-day (4 h/day) whole-body exposure. The aerosol generator, consisting of a novel dustfeed mechanism and venturi ejector was determined to be capable of producing a DWCNT consistently over a 4 h exposure period at an average level of 10.8 mg/m3. The count median diameter was 121 nm with a geometric standard deviation of 2.04. The estimated deposited dose was 32 µg/mouse. The total number of cells in bronchoalveolar lavage (BAL) fluid was significantly (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190025175ZK.pdf | 4197KB | download |