Biological Activation of Inert Ceramics: Recent Advances Using Tailored Self-Assembled Monolayers on Implant Ceramic Surfaces

Materials

Frederik Böke¹  Karolina Schickle¹ 

[1] Department of Dental Materials and Biomaterial Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany;

关键词: alumina;    bioactivation;    self-assembled monolayers;    tissue-integration;    high-strength ceramics;   

DOI  :  10.3390/ma7064473

来源: mdpi

【 摘 要 】

High-strength ceramics as materials for medical implants have a long, research-intensive history. Yet, especially on applications where the ceramic components are in direct contact with the surrounding tissue, an unresolved issue is its inherent property of biological inertness. To combat this, several strategies have been investigated over the last couple of years. One promising approach investigates the technique of Self-Assembled Monolayers (SAM) and subsequent chemical functionalization to create a biologically active tissue-facing surface layer. Implementation of this would have a beneficial impact on several fields in modern implant medicine such as hip and knee arthroplasty, dental applications and related fields. This review aims to give a summarizing overview of the latest advances in this recently emerging field, along with thorough introductions of the underlying mechanism of SAMs and surface cell attachment mechanics on the cell side.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.