Mass Spectrometry Methodology in Lipid Analysis

International Journal of Molecular Sciences

Lin Li¹  Juanjuan Han¹  Zhenpeng Wang¹  Jian𠆚n Liu¹  Jinchao Wei¹  Shaoxiang Xiong¹ 

[1]Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing Mass Spectrum Center, Beijing 100190, China

关键词: lipidomics;    mass spectrometry;    lipids extraction;    bioinformatics technology;   

DOI  :  10.3390/ijms150610492

来源: mdpi

【 摘 要 】

Lipidomics is an emerging field, where the structures, functions and dynamic changes of lipids in cells, tissues or body fluids are investigated. Due to the vital roles of lipids in human physiological and pathological processes, lipidomics is attracting more and more attentions. However, because of the diversity and complexity of lipids, lipid analysis is still full of challenges. The recent development of methods for lipid extraction and analysis and the combination with bioinformatics technology greatly push forward the study of lipidomics. Among them, mass spectrometry (MS) is the most important technology for lipid analysis. In this review, the methodology based on MS for lipid analysis was introduced. It is believed that along with the rapid development of MS and its further applications to lipid analysis, more functional lipids will be identified as biomarkers and therapeutic targets and for the study of the mechanisms of disease.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.