Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial

Nutrients

Julie Carillon¹  Claire Notin³  Karine Schmitt¹  Guy Simoneau² 

[1] Bionov Company, 939 rue de la Croix Verte, Montpellier 34090, France; E-Mails:;Therapeutic Research Unit, Department of Internal Medicine, Lariboisière Hospital, 2 rue Ambroise-Paré, Paris 75010, France; E-Mail:;Seppic Company, 22 Terasse Bellini, Puteaux 92806, France; E-Mail:

关键词: psychological stress;    physical and mental fatigue;    oxidative stress;    melon;    superoxide dismutase;    psychometric scales;   

DOI  :  10.3390/nu6062348

来源: mdpi

【 摘 要 】

Background: We aimed to investigate effects of superoxide dismutase (SOD)-melon concentrate supplementation on psychological stress, physical and mental fatigue in healthy people. Methods: A randomized, double-blind, placebo-controlled trial was performed on 61 people divided in two groups: active supplement (n = 32) and placebo (n = 29) for 12 weeks. Volunteers were given one small hard capsule per day. One capsule contained 10 mg of SOD-melon concentrate (140 U of SOD) and starch for the active supplement and starch only for the placebo. Stress and fatigue were evaluated using four psychometric scales: PSS-14; SF-36; Stroop tests and Prevost scale. Results: The supplementation with SOD-melon concentrate significantly decreased perceived stress, compared to placebo. Moreover, quality of life was improved and physical and mental fatigue were reduced with SOD-melon concentrate supplementation. Conclusion: SOD-melon concentrate supplementation appears to be an effective and natural way to reduce stress and fatigue. Trial registration: trial approved by the ethical committee of Poitiers (France), and the ClinicalTrials.gov Identifier is NCT01767922.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.