Respiratory Effects of Fine and Ultrafine Particles from Indoor Sources—A Randomized Sham-Controlled Exposure Study of Healthy Volunteers

International Journal of Environmental Research and Public Health

Vanessa J. Soppa²  Roel P. F. Schins²  Frauke Hennig²  Bryan Hellack¹  Ulrich Quass¹  Heinz Kaminski¹  Thomas A. J. Kuhlbusch¹  Barbara Hoffmann² 

[1] Air Quality and Sustainable Nanotechnology Unit, Institut für Energie- und Umwelttechnik (IUTA) e.V., Bliersheimer Straße 58–60, 47229 Duisburg, Germany; E-Mails:;IUF-Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225 Düsseldorf, Germany; E-Mails:

关键词: fine and ultrafine particles;    controlled exposure;    indoor sources;    lung function;   

DOI  :  10.3390/ijerph110706871

来源: mdpi

【 摘 要 】

Particulate air pollution is linked to impaired respiratory health. We analyzed particle emissions from common indoor sources (candles burning (CB), toasting bread (TB), frying sausages (FS)) and lung function in 55 healthy volunteers (mean age 33.0 years) in a randomized cross-over controlled exposure study. Lung-deposited particle surface area concentration (PSC), size-specific particle number concentration (PNC) up to 10 µm, and particle mass concentration (PMC) of PM₁, PM_2.5 and PM₁₀ were determined during exposure (2 h). FEV₁, FVC and MEF_25%–75% was measured before, 4 h and 24 h after exposure. Wilcoxon-rank sum tests (comparing exposure scenarios) and mixed linear regression using particle concentrations and adjusting for personal characteristics, travel time and transportation means before exposure sessions were performed. While no effect was seen comparing the exposure scenarios and in the unadjusted model, inverse associations were found for PMC from CB and FS in relation to FEV₁ and MEF_25%–75%. with a change in 10 µg/m³ in PM_2.5 from CB being associated with a change in FEV₁ of −19 mL (95%-confidence interval:−43; 5) after 4 h. PMC from TB and PNC of UFP were not associated with lung function changes, but PSC from CB was. Elevated indoor fine particles from certain sources may be associated with small decreases in lung function in healthy adults.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.