Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice

Marine Drugs

Yajun Yang¹  Jing Ma¹  Jinghui Xiu¹  Lin Bai¹  Feifei Guan¹  Li Zhang¹  Jiangning Liu¹ 

[1] Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China; E-Mails:

关键词: deferoxamine;    enterovirus 71;    hand;    foot and mouth disease;    B cells;   

DOI  :  10.3390/md12074086

来源: mdpi

【 摘 要 】

Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.