Dynamic Constitution of the Pathogens Inducing Encephalitis in Hand, Foot and Mouth Disease in Kunming, 2009–2011

Japanese Journal of Infectious Diseases

Shaohui Ma²  Longding Liu²  Yue Pan²  Junying Chen²  Ying Zhang²  Cengqing Du¹  Qiangming Sun²  Haijing Shi²  Qihan Li²  Qiong Liu¹  Ting Yang² 

[1] Department of Infectious Diseases of Kunming Children's Hospital;Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College

关键词: hand;    foot and mouth disease;    enterovirus 71;    coxsackievirus A 16;    echovirus 9;   

DOI  :  10.7883/yoken.JJID.2014.428

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(24)Cited-By(1)Hand, foot and mouth disease (HFMD), caused by various viral pathogens, is an emerging infectious disease in children in Asia. Understanding the composition of these pathogens is necessary to prevent and control this disease. In the present study, the pathogens in 436 HFMD patients (from 2009 to 2011) with concurrent clinical indications of encephalitis, meningoencephalitis, or both, were defined using the semi-nested PCR. A systematic analysis of the composition of these pathogens was performed. Various enteroviruses that are capable of inducing central nervous system (CNS) damage in HFMD patients were identified, including enterovirus 71, coxsackievirus A16, and Echovirus 9. Most of these pathogens were found co-infecting the patients. The composition of the pathogens that induced CNS damage in the HFMD patients was dynamically modulated in the cases.

【 授权许可】

Unknown