miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1

International Journal of Molecular Sciences

Hui Xia³  Shengjie Sun²  Bo Wang¹  Tao Wang¹  Chaoyang Liang¹  Guo Li¹  Chongbiao Huang⁴  Daliang Qi⁴ 

[1]Department of Thoracic Surgery, the General Hospital of People’s Liberation Army, Beijing 100853, China

[2] E-Mails:

[3]Department of Medical Oncology, the General Hospital of People’s Liberation Army, Beijing 100853, China

[4] E-Mail:

[5]Department of Thoracic-Cardio Surgery, the First Affiliated Hospital of PLA General Hospital, Beijing 100048, China

[6] E-Mail:

[7]Key Laboratory of Cancer Prevention and Therapy of Tianjin, Department of Senior Ward, Tianjin Medical University Cancer Institute and Hospital, Huanhu Xilu, Hexi District, Tianjin 300060, China

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关键词: miR-143;    NSCLC;    Limk1;    proliferation;    migration;    invasion;   

DOI  :  10.3390/ijms150711973

来源: mdpi

【 摘 要 】

MicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the roles and mechanisms of miR-143 in non-small cell lung cancer (NSCLC). miR-143 was significantly decreased in NSCLC tissues and cell lines. Overexpression of miR-143 suppressed NSCLC cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct and functional target of miR-143. Overexpression of Limk1 attenuated the tumor suppressive effects of miR-143 in NSCLC cells. Moreover, miR-143 was inversely correlated with Limk1 expression in NSCLC tissues. Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.