Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment

Pathogens

Agnieszka Lawrenczyk¹  Seil Kim²  Xiangshu Wen²  Ran Xiong² 

[1] Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;

关键词: HBV;    NKT;    humanized mice;    antivirals;    immunotherapy;   

DOI  :  10.3390/pathogens3030563

来源: mdpi

【 摘 要 】

CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. Both mouse modeling experiments and human clinical studies have suggested a key role for iNKT cells in anti-HBV immunity and these potent T cells can be explored as a novel therapeutic target for anti-HBV treatment. We aim to humanize mice in the CD1d/iNKT cell lipid presentation system and provide new research tools for identifying novel anti-HBV agents.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.