Resveratrol Increases Nephrin and Podocin Expression and Alleviates Renal Damage in Rats Fed a High-Fat Diet

Nutrients

Qing-Rong Pan²  Yan-Long Ren¹  Jia-Jia Zhu¹  Yan-Jin Hu²  Jin-Su Zheng³  Hui Fan²  Yuan Xu²  Guang Wang² 

[1] Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China; E-Mails:;Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; E-Mails:;Department of Traditional Chinese Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China; E-Mail:

关键词: resveratrol;    NF-κB;    TNF-α;    MCP-1;    nephrin;    podocin;   

DOI  :  10.3390/nu6072619

来源: mdpi

【 摘 要 】

Resveratrol is well known for its anti-inflammation and anti-oxidant properties, and has been shown to be effective in alleviating the development of obesity. The purpose of this investigation was to analyze the effect of resveratrol on renal damage in obese rats induced by a high-fat diet (HFD) and its possible mechanisms. Male Sprague-Dawley rats were divided into three groups: control, HFD, and HFD plus resveratrol (treated with 100 mg/kg/day resveratrol). Body weight, serum and urine metabolic parameters, and kidney histology were measured. Meanwhile, the activities of nuclear factor-κB (NF-κB) and superoxide dismutase (SOD), the content of malondialdehyde (MDA), and the protein levels of tumor necrosis factor (TNF-α), monocyte chemotactic protein-1 (MCP-1), nephrin and podocin in kidney were detected. Our work showed that resveratrol alleviated dyslipidemia and renal damage induced by HFD, decreased MDA level and increased SOD activity. Furthermore, the elevated NF-κB activity, increased TNF-α and MCP-1 levels, and reduced expressions of nephrin and podocin induced by HFD were significantly reversed by resveratrol. These results suggest resveratrol could ameliorate renal injury in rats fed a HFD, and the mechanisms are associated with suppressing oxidative stress and NF-κB signaling pathway that in turn up-regulate nephrin and podocin protein expression.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.