Thuringiensin: A Thermostable Secondary Metabolite from Bacillus thuringiensis with Insecticidal Activity against a Wide Range of Insects

Toxins

Xiaoyan Liu²  Lifang Ruan¹  Donghai Peng¹  Lin Li¹  Ming Sun¹ 

[1] State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; E-Mails:;Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan 430064, China; E-Mail:

关键词: thuringiensin;    Bacillus thuringiensis;    insecticidal mechanism;    genetic determinants;   

DOI  :  10.3390/toxins6082229

来源: mdpi

【 摘 要 】

Thuringiensin (Thu), also known as β-exotoxin, is a thermostable secondary metabolite secreted by Bacillus thuringiensis. It has insecticidal activity against a wide range of insects, including species belonging to the orders Diptera, Coleoptera, Lepidoptera, Hymenoptera, Orthoptera, and Isoptera, and several nematode species. The chemical formula of Thu is C₂₂H₃₂O₁₉N₅P, and it is composed of adenosine, glucose, phosphoric acid, and gluconic diacid. In contrast to the more frequently studied insecticidal crystal protein, Thu is not a protein but a small molecule oligosaccharide. In this review, a detailed and updated description of the characteristics, structure, insecticidal mechanism, separation and purification technology, and genetic determinants of Thu is provided.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.