Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety

Molecules

Yanwei Wang¹  Kehan Xu¹  Guojing Bai¹  Lei Huang¹  Qiuye Wu¹  Weihua Pan² 

[1] Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China;Shanghai Key Laboratory of Molecular Medical Mycology, Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China

关键词: antifungal;    triazole;    synthesis;    piperazine;   

DOI  :  10.3390/molecules190811333

来源: mdpi

【 摘 要 】

Design and synthesis of triazole library antifungal agents having piperazine side chains, analogues to fluconazole were documented. The synthesis highlighted utilization of the click chemistry on the basis of the active site of the cytochrome P450 14α-demethylase (CYP51). Their structures were characterized by ¹H-NMR, ¹³C-NMR, MS and IR. The influences of piperazine moiety on in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.