Health Resource Utilization Associated with Skeletal-Related Events in Patients with Advanced Prostate Cancer: A European Subgroup Analysis from an Observational, Multinational Study

Journal of Clinical Medicine

Amit Bahl⁸  Herbert Hoefeler⁴  Ignacio Duran¹⁰  Guy Hechmati⁶  Cristina Garzon-Rodriguez⁹  John Ashcroft²  Vito Lorusso⁵  Prayashi Ghelani⁷  Rachel Wei¹  Emma Thomas^3,8 

[1] Biostatistics, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA 91320, USA; E-Mail:;Pinderfields General Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield WF1 4DG, UK; E-Mail:;Scientific Publications, Amgen (Europe) GmbH, Dammstrasse 23, 6301 Zug, Switzerland; E-Mail:;Research Centre Ruhr, Pferdebach Street 30, Witten 58455, Germany; E-Mail:;National Cancer Institute IRCCS Giovanni Paolo II, Viale Orazio Flacco 65, 70124, Bari, Italy; E-Mail:;Health Economics, Amgen (Europe) GmbH, Dammstrasse 23, Zug 6301, Switzerland; E-Mail:;Biostatistics, Ovatech Solutions, 112 Morden Road Abbey, London SW19 2NA, UK; E-Mail:;University Hospitals Bristol, Bristol Royal Infirmary, Upper Maudlin St., Bristol, Avon BS2 8HW, UK;Institute of Oncology Catalá ICO-IDIBELL, Avenue Gran Via de l’Hospitalet, 199-203, Hospitalet de Llobregat, Barcelona 08908, Spain; E-Mail:;Integrated Cancer Centre Clara Campal (CIOCC), Calle Oña 10, Madrid 28050, Spain; E-Mail:

关键词: bone metastases;    Europe;    health resource utilization;    prostate cancer;    skeletal-related events;   

DOI  :  10.3390/jcm3030883

来源: mdpi

【 摘 要 】

This study aimed to increase the understanding of health resource utilization (HRU) associated with skeletal-related events (SREs) occurring in patients with bone metastases secondary to advanced prostate cancer. A total of 120 patients from Germany, Italy, Spain and the United Kingdom were enrolled in this observational study. They had bone metastases secondary to prostate cancer and had experienced at least one SRE in the 97 days before giving informed consent. HRU data were collected retrospectively for 97 days before enrolment and prospectively for up to 18–21 months. HRU, including the number and duration of inpatient hospitalizations, number of outpatient and emergency department visits and procedures, was independently attributed by investigators to an SRE. Of the 222 SREs included in this analysis, 26% were associated with inpatient stays and the mean duration per SRE was 21.4 days (standard deviation (SD) 17.8 days). Overall, 174 SREs (78%) required an outpatient visit and the mean number of visits per SRE was 4.6 (SD 4.6). All SREs are associated with substantial HRU. Preventing SREs in patients with advanced prostate cancer and bone metastases may help to reduce the burden to both patients and European healthcare systems.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.