The Role of 18F-Sodium Fluoride PET/CT Bone Scans in the Diagnosis of Metastatic Bone Disease from Breast and Prostate Cancer

Journal of Nuclear Medicine Technology

Sobhan Vinjamuri¹  Peter Hogg¹  Randeep Kumar Kulshrestha¹  Andrew England¹  Julie Nightingale¹ 

关键词: ¹⁸F-sodium fluoride PET/CT;    ^99mTc-MDP;    bone scintigraphy;    bone metastases;    breast cancer;    prostate cancer;   

DOI  :  10.2967/jnmt.116.176859

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

We describe the role of 18F-sodium fluoride (18F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer. 18F-NaF PET was initially utilized as a bone scanning agent in the 1960s and early 1970s, however, its use was restricted by the then-available γ-cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its use and role. After a brief introduction, this paper describes the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of 18F-NaF. The performance of 18F-NaF PET/CT is then compared with that of conventional bone scintigraphy using current evidence from the literature. Strengths and weaknesses of 18F-NaF PET/CT imaging are highlighted. Clinical examples of improved accuracy of diagnosis and impact on patient management are illustrated. Limitations of 18F-NaF PET/CT imaging are outlined.

【 授权许可】

Unknown