Toxins | |
Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery | |
Philip A. Gurnev1  | |
[1] Physics Department, University of Massachusetts, Amherst, MA 01003, USA; E-Mail: | |
关键词: gramicidin A; α-hemolysin; anthrax toxin; biosensing; stochastic sensing; ion channel; biological nanopore; protein translocation; targeted toxins; drug delivery; polymer transport; | |
DOI : 10.3390/toxins6082483 | |
来源: mdpi | |
【 摘 要 】
To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides. Recent developments in single-channel electrical recordings, X-ray crystallography, protein engineering, and computational methods have generated a large body of knowledge about the basic principles of channel-mediated molecular transport. These discoveries provide a robust framework for expansion of the described principles and methods toward use of biological nanopores in the growing field of nanobiotechnology. This article, written for a special volume on “
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190022735ZK.pdf | 1815KB | download |