Single-Molecule Study of Proteins by Biological Nanopore Sensors

Sensors

Dongmei Wu¹  Sheng Bi²  Liyu Zhang¹ 

[1] College of Pharmacy, Jiamusi University, Jiamusi 154007, China; E-Mail:;The Affiliated First Hospital of Jiamusi University, Jiamusi 154007, China; E-Mail:

关键词: α-hemolysin;    protein conformation;    protein-ligand interactions;    new nanopores;   

DOI  :  10.3390/s141018211

来源: mdpi

【 摘 要 】

Nanopore technology has been developed for detecting properties of proteins through monitoring of ionic current modulations as protein passes via a nanosize pore. As a real-time, sensitive, selective and stable technology, biological nanopores are of widespread concern. Here, we introduce the background of nanopore researches in the area of α-hemolysin (α-HL) nanopores in protein conformation detections and protein–ligand interactions. Moreover, several original biological nanopores are also introduced with various features and functions.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.