Fermentation with Aquilariae Lignum Enhances the Anti-Diabetic Activity of Green Tea in Type II Diabetic db/db Mouse

Nutrients

Su Jin Kang³  Ji Eun Lee³  Eun Kyung Lee³  Dae Hwa Jung⁴  Chang Hyun Song³  Soo Jin Park³  Seong Hun Choi¹  Chang Hyun Han²  Sae Kwang Ku³ 

[1] Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 712-715, Korea; E-Mail:;Department of Medical History & Literature Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea; E-Mail:;The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea; E-Mails:;HaniBio, Gyeongsan 712-260, Korea; E-Mail:

关键词: BKS.Cg-+Leprdb/+Leprdb/OlaHsd (db/db) mice;    obese;    diabetes;    fermented green tea with Aquilariae Lignum;    synergistic;   

DOI  :  10.3390/nu6093536

来源: mdpi

【 摘 要 】

The major components of tea may be significantly influenced according to the type of fermentation, and consequently the effects of different teas will differ. We examined whether green tea fermented with Aquilariae Lignum (fGT) shows a stronger anti-diabetic effect than unfermented green tea (GT) on mice with type 2 diabetes. To evaluate the anti-obesity effect of fGT, we assessed body weight, fecal excretion, serum leptin levels, exocrine pancreatic zymogen granule contents, and periovarian fat weight and adiponectin contents. Blood glucose levels, pancreatic weight, and numbers of pancreatic islet insulin- and glucagon-producing cells were determined to evaluate anti-hypoglycemic effects, while total cholesterol, triglyceride, and low- and high-density lipoprotein levels were determined to evaluate anti-hyperlipidemic effects. The antioxidant effect of fGT was detected by measuring malondialdehyde and glutathione contents and the activities of catalase and superoxide dismutase. fGT showed anti-obesity, anti-hypoglycemic, anti-hyperlipidemia, and antioxidant effects. Additionally, fGT exerted stronger anti-diabetic effects compared with GT. Collectively, these results suggested that fGT fermented with the appropriate amounts of Aquilariae Lignum (49:1) has a stronger effect compared with GT. Thus, fGT is a promising and potent new therapeutic agent for type 2 diabetes.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.