Recruitment and Baseline Characteristics of Participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)—A Randomized Controlled Lifestyle Trial †

International Journal of Environmental Research and Public Health

Tiia Ngandu⁸  Jenni Lehtisalo⁸  Esko Levälahti⁸  Tiina Laatikainen⁸  Jaana Lindström⁸  Markku Peltonen⁸  Alina Solomon⁷  Satu Ahtiluoto⁸  Riitta Antikainen²  Tuomo Hänninen⁹  Antti Jula⁸  Francesca Mangialasche⁵  Teemu Paajanen³  Satu Pajala⁶  Rainer Rauramaa¹  Timo Strandberg²  Jaakko Tuomilehto¹⁰  Hilkka Soininen^4,8 

[1] Kuopio Research Institute of Exercise Medicine, Kuopion yliopisto, Haapaniementie 16, 70100 Kuopio, Finland; E-Mail:;Institute of Health Sciences/Geriatrics, University of Oulu, and Oulu University Hospital, P.O. Box 5000, FI-90014 University of Oulu, Finland; E-Mails:;Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland; E-Mail:;Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland; E-Mails:;Aging Research Center, Karolinska Institutet—Stockholm University, Gävlegatan 16, SE-11330 Stockholm, Sweden; E-Mail:;Department of Lifestyle and Participation, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland; E-Mail:;Alzheimer’s Disease Research Center, Karolinska Institutet, Novum 5th floor, SE-14157 Stockholm, Sweden;Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland; E-Mails:;Department of Neurology, Kuopio University Hospital, P.O. Box 100, FI-70029 KYS, Kuopio, Finland; E-Mail:;Department of Public Health, University of Helsinki, P.O. Box 40, FI-00014 University of Helsinki, Finland; E-Mail:

关键词: cognitive impairment;    dementia;    Alzheimer’s disease;    lifestyle;    intervention;    randomized controlled trial;   

DOI  :  10.3390/ijerph110909345

来源: mdpi

【 摘 要 】

Our aim is to describe the study recruitment and baseline characteristics of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) study population. Potential study participants (age 60–77 years, the dementia risk score ≥6) were identified from previous population-based survey cohorts and invited to the screening visit. To be eligible, cognitive performance measured at the screening visit had to be at the mean level or slightly lower than expected for age. Of those invited (n = 5496), 48% (n = 2654) attended the screening visit, and finally 1260 eligible participants were randomized to the intervention and control groups (1:1). The screening visit non-attendees were slightly older, less educated, and had more vascular risk factors and diseases present. The mean (SD) age of the randomized participants was 69.4 (4.7) years, Mini-Mental State Examination 26.7 (2.0) points, systolic blood pressure 140.1 (16.2) mmHg, total serum cholesterol 5.2 (1.0) mmol/L for, and fasting glucose 6.1 (0.9) mmol/L for, with no difference between intervention and control groups. Several modifiable risk factors were present at baseline indicating an opportunity for the intervention. The FINGER study will provide important information on the effect of lifestyle intervention to prevent cognitive impairment among at risk persons.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.