Vitamin E Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy

Nutrients

Daniella J. Itinoseki Kaio²  Patricia Helen C. Rondó²  Liania Alves Luzia²  José Maria P. Souza¹  Aline Vale Firmino² 

[1] Department of Epidemiology, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil; E-Mail:;Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil; E-Mails:

关键词: alpha-tocopherol;    vitamin E;    micronutrients;    HIV;    HAART;   

DOI  :  10.3390/nu6093641

来源: mdpi

【 摘 要 】

HIV/AIDS patients are probably more predisposed to vitamin E deficiency, considering that they are more exposed to oxidative stress. Additionally, there are an extensive number of drugs in the highly active antiretroviral therapy (HAART) regimens that may interfere with vitamin E concentrations. The objective of this study was to compare serum concentrations of alpha-tocopherol in 182 HIV/AIDS patients receiving different HAART regimens. The patients were divided into three groups according to regimen: nucleoside analog reverse-transcriptase inhibitors (NRTIs) + non-nucleoside analog reverse-transcriptase inhibitors (NNRTIs); NRTIs + protease inhibitors + ritonavir; NRTIs + other classes. Alpha-tocopherol was assessed by high-performance liquid chromatography. Multiple linear regression analysis was used to evaluate the effects of HAART regimen, time of use, and compliance with the regimen on alpha-tocopherol concentrations. Alpha-tocopherol concentrations were on average 4.12 μmol/L lower for the NRTIs + other classes regimen when compared to the NRTIs + NNRTIs regimen (p = 0.037). A positive association (p < 0.001) was observed between alpha-tocopherol and cholesterol concentrations, a finding due, in part, to the relationship between liposoluble vitamins and lipid profile. This study demonstrated differences in alpha-tocopherol concentrations between patients using different HAART regimens, especially regimens involving the use of new drugs. Long-term prospective cohort studies are needed to monitor vitamin E status in HIV/AIDS patients since the beginning of treatment.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.