期刊论文详细信息
Molecules | |
Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and |
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Marc Montana1  Florian Correard2  Omar Khoumeri1  Marie-Anne Esteve2  Thierry Terme1  | |
[1] Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France; E-Mails:;Aix-Marseille Université, INSERM, CRO2, UMR_S911, Marseille 13385, France; E-Mails: | |
关键词: quinoxaline; TDAE; XK469; isatin; oxirane; neuroblastoma; anti-cancer drugs; | |
DOI : 10.3390/molecules190914987 | |
来源: mdpi | |
【 摘 要 】
Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities.
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190021818ZK.pdf | 814KB | download |