Original TDAE Strategy Using Propargylic Chloride:Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

Molecules

Manon Roche¹  Thierry Terme¹ 

[1] Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France

关键词: TDAE;    propargylic alcohol;    organic reducing agent;    aromatic aldehyde;   

DOI  :  10.3390/molecules18021540

来源: mdpi

【 摘 要 】

We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis(dimethylamino)ethylene (TDAE) as reductant.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.