The Structural and Functional Coordination of Glycolytic Enzymes in Muscle: Evidence of a Metabolon?

Biology

Lynda Menard²  David Maughan¹ 

[1] Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA; E-Mail:;Department of Biology, University of Vermont, Burlington, VT 05405, USA; E-Mail:

关键词: glycolytic metabolon;    enzyme complex;    muscle;    metabolism;    homeostasis;   

DOI  :  10.3390/biology3030623

来源: mdpi

【 摘 要 】

Metabolism sustains life through enzyme-catalyzed chemical reactions within the cells of all organisms. The coupling of catalytic function to the structural organization of enzymes contributes to the kinetic optimization important to tissue-specific and whole-body function. This coupling is of paramount importance in the role that muscle plays in the success of Animalia. The structure and function of glycolytic enzyme complexes in anaerobic metabolism have long been regarded as a major regulatory element necessary for muscle activity and whole-body homeostasis. While the details of this complex remain to be elucidated through in vivo studies, this review will touch on recent studies that suggest the existence of such a complex and its structure. A potential model for glycolytic complexes and related subcomplexes is introduced.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.