International Journal of Environmental Research and Public Health | |
Genomic Instability in Human Lymphocytes from Male Users of Crack Cocaine | |
Thiago Aley Brites de Freitas2  Roberta Passos Palazzo2  Fabiana Michelsen de Andrade1  César Luis Reichert1  Flávio Pechansky4  Félix Kessler4  Caroline Brunetto de Farias3  Gisele Gomes de Andrade2  Sandra Leistner-Segal2  | |
[1] Health Science Institute, Feevale University, RS 239, Novo Hamburgo, RS 93352-000, Brazil; E-Mails:;Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035-903, Brazil; E-Mails:;Laboratório de Pesquisas em Câncer, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035-903, Brazil; E-Mail:;Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre and Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-903, Brazil; E-Mails: | |
关键词: crack cocaine; drug withdrawal; DNA damage; comet assay; micronucleus; | |
DOI : 10.3390/ijerph111010003 | |
来源: mdpi | |
【 摘 要 】
Recent research suggests that crack cocaine use alters systemic biochemical markers, like oxidative damage and inflammation markers, but very few studies have assessed the potential effects of crack cocaine at the cellular level. We assessed genome instability by means of the comet assay and the cytokinesis-block micronucleus technique in crack cocaine users at the time of admission to a rehabilitation clinic and at two times after the beginning of withdrawal. Thirty one active users of crack cocaine and forty control subjects were evaluated. Comparison between controls and crack cocaine users at the first analysis showed significant differences in the rates of DNA damage (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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