Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis

Cancers

Olivia L. George¹ 

关键词: chromatin;    gene regulation;    cyclins;    post-translational modifications;    cancer;    salivary gland;    epithelia;    differentiation;    RNA splicing;    signaling;   

DOI  :  10.3390/cancers6042049

来源: mdpi

【 摘 要 】

This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.