Epigenetics and the dynamics of chromatin during adenovirus infections

FEBS Letters

article

Kelsey L. Lynch¹  Linda R. Gooding²  Charlie Garnett-Benson³  David A. Ornelles⁴  Daphne C. Avgousti¹ 

[1] Human Biology Division, Fred Hutchinson Cancer Research Center;Department of Microbiology and Immunology, Emory University School of Medicine;Department of Biology, Georgia State University;Department of Microbiology and Immunology, Wake Forest School of Medicine

关键词: adenovirus;    chromatin;    E1A;    epigenetics;    histones;    host-pathogen interactions;    persistence;    post-translational modifications;    protein VII;   

DOI  :  10.1002/1873-3468.13697

来源: John Wiley & Sons Ltd.

【 摘 要 】

The DNA genome of eukaryotic cells is compacted by histone proteins within the nucleus to form chromatin. Nuclear-replicating viruses such as adenovirus have evolved mechanisms of chromatin manipulation to promote infection and subvert host defenses. Epigenetic factors may also regulate persistent adenovirus infection and reactivation in lymphoid tissues. In this review, we discuss the viral proteins E1A and protein VII that interact with and alter host chromatin, as well as E4orf3, which separates host chromatin from sites of viral replication. We also highlight recent advances in chromatin technologies that offer new insights into virus-directed chromatin manipulation. Beyond the role of chromatin in the viral replication cycle, we discuss the nature of persistent viral genomes in lymphoid tissue and cell lines, and the potential contribution of epigenetic signals in maintaining adenovirus in a quiescent state. By understanding the mechanisms through which adenovirus manipulates host chromatin, we will understand new aspects of this ubiquitous virus and shed light on previously unknown aspects of chromatin biology.

【 授权许可】

Unknown