Dielectrophoresis for Bioparticle Manipulation

International Journal of Molecular Sciences

Cheng Qian²  Haibo Huang¹  Liguo Chen²  Xiangpeng Li²  Zunbiao Ge²  Tao Chen²  Zhan Yang²  Lining Sun² 

[1] obotics and Microsystems Center, College of Mechanical and Electrical Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215000, China;

关键词: dielectrophoresis;    lab-on-a-chip;    bioparticle;    trapping;    detection;    focusing;    pairing;    separation;   

DOI  :  10.3390/ijms151018281

来源: mdpi

【 摘 要 】

As an ideal method to manipulate biological particles, the dielectrophoresis (DEP) technique has been widely used in clinical diagnosis, disease treatment, drug development, immunoassays, cell sorting, etc. This review summarizes the research in the field of bioparticle manipulation based on DEP techniques. Firstly, the basic principle of DEP and its classical theories are introduced in brief; Secondly, a detailed introduction on the DEP technique used for bioparticle manipulation is presented, in which the applications are classified into five fields: capturing bioparticles to specific regions, focusing bioparticles in the sample, characterizing biomolecular interaction and detecting microorganism, pairing cells for electrofusion and separating different kinds of bioparticles; Thirdly, the effect of DEP on bioparticle viability is analyzed; Finally, the DEP techniques are summarized and future trends in bioparticle manipulation are suggested.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.