Heparin Assisted Photochemical Synthesis of Gold Nanoparticles and Their Performance as SERS Substrates

International Journal of Molecular Sciences

Maria del Pilar Rodríguez-Torres¹  Luis Armando D໚z-Torres¹  Sergio Romero-Servin² 

[1]Grupo de Espectroscopia de Materiales Avanzados y Nanoestructurados (GEMANA), Centro de Investigaciones en Óptica, A.C., Loma del Bosque 115, León, Guanajuato, C.P. 37150, Mexico

[2] E-Mail:

[3]Centro de Investigaciones en Óptica, A.C., Loma del Bosque 115, León, Guanajuato, C.P. 37150, Mexico

[4] E-Mail:

关键词: heparin;    gold nanoparticles;    photochemistry;    SERS;    organic dyes;   

DOI  :  10.3390/ijms151019239

来源: mdpi

【 摘 要 】

Reactive and pharmaceutical-grade heparins were used as biologically compatible reducing and stabilizing agents to photochemically synthesize colloidal gold nanoparticles. Aggregates and anisotropic shapes were obtained photochemically under UV black-light lamp irradiation (λ = 366 nm). Heparin-functionalized gold nanoparticles were characterized by Scanning Electron Microscopy and UV-Vis spectroscopy. The negatively charged colloids were used for the Surface Enhanced Raman Spectroscopy (SERS) analysis of differently charged analytes (dyes). Measurements of pH were taken to inspect how the acidity of the medium affects the colloid-analyte interaction. SERS spectra were taken by mixing the dyes and the colloidal solutions without further functionalization or addition of any aggregating agent.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.