Advances in Metal-Catalyzed Cross-Coupling Reactions of Halogenated Quinazolinones and Their Quinazoline Derivatives

Molecules

Malose Jack Mphahlele¹  Marole Maria Maluleka² 

[1] Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa; E-Mail

关键词: halogenoquinazolin-4-ones;    halogenoquinazolines;    cross-coupling reactions;   

DOI  :  10.3390/molecules191117435

来源: mdpi

【 摘 要 】

Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon–carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or carbon-heteroatom bond formation via the Buchwald-Hartwig cross-coupling to yield novel polysubstituted derivatives. This review presents an overview of the application of these methods on halogenated quinazolin-4-ones and their quinazolines to generate novel polysubstituted derivatives.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.