Recent Progress in the Use of Pd-Catalyzed C-C Cross-Coupling Reactions in the Synthesis of Pharmaceutical Compounds

Journal of the Brazilian Chemical Society

André F. P. Biajoli¹  Cristiane S. Schwalm¹  Jones Limberger¹  Thiago S. Claudino¹  Adriano L. Monteiro¹ 

关键词: cross-coupling reactions;    Heck reactions;    palladium;    pharmaceuticals;   

DOI  :  10.5935/0103-5053.20140255

来源: SciELO

【 摘 要 】

The impressive ability of palladium to assemble C-C bonds between appropriately functionalized substrates has allowed synthetic organic chemists to perform transformations that were previously impossible or only possible using multi-step approaches. In this context, one of the most important and elegant applications of the Pd-catalyzed C-C coupling reactions currently is the synthesis of pharmaceuticals. This review is intended to give a picture of the applications of Pd-catalyzed C-C cross-coupling reactions for the synthesis of drug components or drug candidates regardless of the scale from 2011 through to the end of July, 2014.

【 授权许可】

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