Antioxidant Capacity, Cytotoxicity and Antimycobacterial Activity of Madeira Archipelago Endemic Helichrysum Dietary and Medicinal Plants

Antioxidants

Sandra C. Gouveia-Figueira³  Carla A. Gouveia³  Maria J. Carvalho³  Ana I. Rodrigues¹  Malin L. Nording²  Paula C. Castilho³  Maria G. Migue⁴ 

[1] Unidade de Geologia Marinha, Laboratório Nacional de Energia e Geologia, I.P., Estrada da Portela, Zambujal—Alfragide Apartado 7586, Amadoram 2720-866, Portugal; E-Mail:;Department of Chemistry, Umeå University, Umeå SE-901 87, Sweden; E-Mail:;Centro de Química da Madeira, CCCEE, Universidade da Madeira, Campus Universitário da Penteada, piso 0, Funchal 9000-390, Portugal; E-Mails:Centro de Química da Madeira, CCCEE, Universidade da Madeira, Campus Universitário da Penteada, piso 0, Funchal 9000-390, Portugal;

关键词: antioxidant;    antimycobacterial;    Artemia salina;    Helichrysum;    chemometrics;   

DOI  :  10.3390/antiox3040713

来源: mdpi

【 摘 要 】

The potential bioactivity of dietary and medicinal endemic Helichrysum plants from Madeira Archipelago was explored, for the first time, in order to supply new information for the general consumer. In vitro antioxidant properties were investigated using DPPH, ABTS^•+, FRAP and β-Carotene assays, and the total phenolic content (TPC) and total flavonoid content (TFC) were also determined. Although the results generally showed a large variation among the three analyzed plants, the methanolic extracts showed the highest antioxidant capacity. Exception is made for H. devium n-hexane extract that showed good radical scavenger capacity associated to compounds with good reducing properties. In the Artemia salina toxicity assay and antimycobaterial activity, H. devium was the most potent plant with the lowest LD₅₀ at 216.7 ± 10.4 and MIC ≤ 50 μg·mL⁻¹. Chemometric evaluation (Principal Component Analysis—PCA) showed close interdependence between the ABTS, TPC and TFC methods and allowed to group H. devium samples.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.