Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant

Molecules

Javid Hussain²  Liaqat Ali¹  Abdul Latif Khan¹  Najeeb Ur Rehman¹  Farah Jabeen¹  Jong-Sang Kim³  Ahmed Al-Harrasi² 

[1]UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman

[2] E-Mails:

[3]Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman

[4]School of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Korea

[5] E-Mail:

关键词: flavonoid;    morin;    Acridocarpus orientalis;    Malpighiaceae;    antioxidant;    lipid peroxidation;    cytotoxicity;   

DOI  :  10.3390/molecules191117763

来源: mdpi

【 摘 要 】

Acridocarpus orientalis is an important medicinal plant for some of the locals of Arabian region. Very little is known about its phytochemical constituents. In the present study, we aimed to isolate bioactive chemicals from the crude methanolic extract of the aerial parts of A. orientalis. The extraction and isolation resulted in the purification of two flavonoids: morin (1) and morin-3-O-β-D-glucopyranoside (2). The structure elucidation was carried out by extensive analysis of spectroscopic data and comparison with the reported data for the known constituents. The pure isolates were subjected to various biological assays for their bioactivities. The compounds 1 and 2 were significantly active against the growth of various pathogenic fungi and phytotoxic against lettuce seed at higher concentrations. Furthermore, the free radical scavenging activities, anti-lipid peroxidation, and cytotoxic effects against HepG2, HT29, and HCT116 cancer cell lines were also assayed and the results are presented in this paper.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.