Absorbability, Mechanism and Structure-Property Relationship of Three Phenolic Acids from the Flowers of Trollius chinensis

Molecules

Xiu-Wen Wu²  Ru-Feng Wang¹  Li-Jia Liu²  Li-Na Guo²  Can Zhao² 

[1] School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;

关键词: Trollius chinensis;    Ranunculaceae;    phenolic acids;    absorbability;    Caco-2 cell monolayer model;   

DOI  :  10.3390/molecules191118129

来源: mdpi

【 摘 要 】

The absorption properties, mechanism of action, and structure-property relationship of three phenolic acids isolated from the flowers of Trollius chinensis Bunge, namely, proglobeflowery acid (PA), globeflowery acid (GA) and trolloside (TS), were investigated using the human Caco-2 cell monolayer model. The results showed that these three phenolic acids were transported across the Caco-2 cell monolayer in a time and concentration dependent manner at the P_app level of 10⁻⁵ cm/s, and their extent of absorption correlated with their polarity and molecular weight. In conclusion, all three of these compounds were easily absorbed through passive diffusion, which implied their high bioavailability and significant contribution to the effectiveness of T. chinensis.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.