Antioxidant and Anticancer Aporphine Alkaloids from the Leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena

Molecules

Chi-Ming Liu²  Chiu-Li Kao²  Hui-Ming Wu¹  Wei-Jen Li¹  Cheng-Tsung Huang¹  Hsing-Tan Li¹  Chung-Yi Chen¹ 

[1] School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan; E-Mails:;Tzu Hui Institute of Technology, Pingtung County 92641, Taiwan; E-Mails:

关键词: Nelumbo nucifera Gaertn. cv. Rosa-plena;    aporphine;    antioxidation;    7-hydroxydehydronuciferine;   

DOI  :  10.3390/molecules191117829

来源: mdpi

【 摘 要 】

Fifteen compounds were extracted and purified from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena. These compounds include liriodenine (1), lysicamine (2), (−)-anonaine (3), (−)-asimilobine (4), (−)-caaverine (5), (−)-N-methylasimilobine (6), (−)-nuciferine (7), (−)-nornuciferine (8), (−)-roemerine (9), 7-hydroxydehydronuciferine (10) cepharadione B (11), β-sitostenone (12), stigmasta-4,22-dien-3-one (13) and two chlorophylls: pheophytin-a (14) and aristophyll-C (15). The anti-oxidation activity of the compounds was examined by antiradical scavenging, metal chelating and ferric reducing power assays. The results have shown that these compounds have antioxidative activity. The study has also examined the antiproliferation activity of the isolated compounds against human melanoma, prostate and gastric cancer cells. The results shown that 7-hydroxydehydronuciferine (10) significantly inhibited the proliferation of melanoma, prostate and gastric cancer cells. Together, these findings suggest that leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena are a good resource for obtaining the biologically active substances with antioxidant properties.

【 授权许可】

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