The Global Contribution of Outdoor Air Pollution to the Incidence, Prevalence, Mortality and Hospital Admission for Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health

Qingkun Song²  David C. Christiani³  Xiaorong Wang¹  Jun Ren² 

[1] The Chinese University of Hong Kong, Hong Kong 999077, China; E-Mail:;Beijing Key Laboratory of Cancer Therapeutic Vaccine, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Tie Yi Road 10, Haidian District, Beijing 100038, China; E-Mail:;Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA; E-Mail:

关键词: ambient air pollution;    chronic obstructive pulmonary disease;    environmental health;    epidemiology;    particulate matter;   

DOI  :  10.3390/ijerph111111822

来源: mdpi

【 摘 要 】

Objective: This study aimed to investigate the quantitative effects of outdoor air pollution, represented by 10 µg/m³ increment of PM₁₀, on chronic obstructive pulmonary disease in China, United States and European Union through systematic review and meta-analysis. Methods: Publications in English and Chinese from PubMed and EMBASE were selected. The Cochrane Review Handbook of Generic Inverse Variance was used to synthesize the pooled effects on incidence, prevalence, mortality and hospital admission. Results: Outdoor air pollution contributed to higher incidence and prevalence of COPD. Short-term exposure was associated with COPD mortality increased by 6%, 1% and 1% in the European Union, the United States and China, respectively (p < 0.05). Chronic PM exposure produced a 10% increase in mortality. In a short-term exposure to 10 µg/m³ PM₁₀ increment COPD mortality was elevated by 1% in China (p < 0.05) and hospital admission enrollment was increased by 1% in China, 2% in United States and 1% in European Union (p < 0.05). Conclusions: Outdoor air pollution contributes to the increasing burdens of COPD.10 µg/m³ increase of PM₁₀ produced significant condition of COPD death and exacerbation in China, United States and European Union. Controlling air pollution will have substantial benefit to COPD morbidity and mortality.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.