Vitamin D and Psoriasis Pathology in the Mediterranean Region, Valencia (Spain)

International Journal of Environmental Research and Public Health

Maria Morales Suárez-Varela²  Paloma Reguera-Leal²  William B. Grant¹  Nuria Rubio-López²  Agustín Llopis-González² 

[1] Sunlight, Nutrition and Health Research Center, P.O. Box 641603, San Francisco, CA 94164, USA; E-Mail:;Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain; E-Mails:

关键词: vitamin D;    psoriasis;    Mediterranean region;    diet;   

DOI  :  10.3390/ijerph111212108

来源: mdpi

【 摘 要 】

Vitamin D has important immunomodulatory effects on psoriasis in the Mediterranean region. To measure vitamin D intake in subjects with and without psoriasis, and to find an association with relevant clinical features, a case-control study was performed using cases (n = 50, 50% participation rate) clinically diagnosed with psoriasis and 200 healthy subjects (39.5% participation rate), leaving a final sample of 104 people. A survey was conducted using a food frequency questionnaire and clinical histories. Cases and controls were compared using univariate and multivariate analyses. We observed insufficient intake of cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2) for both cases and controls. Patients with psoriasis were at greater risk of associated pathologies: dyslipidaemia (OR: 3.6, 95% CI: 0.8–15.2); metabolic syndrome (OR: 3.3, 95% CI: 0.2–53.9); hypertension (OR: 1.7, 95% CI: 0.4–7.2). Insufficient vitamin D intake in both psoriasis patients and controls in the Mediterranean population, and cardiovascular comorbility is more frequent in patients with psoriasis.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.