Genotypic Analysis of Kaposi’s Sarcoma-Associated Herpesvirus from Patients with Kaposi’s Sarcoma in Xinjiang, China

Viruses

Xinxing Ouyang²  Yan Zeng¹  Bishi Fu²  Xiaowu Wang³  Wei Chen³  Yuan Fang³  Minhua Luo²  Linding Wang³ 

[1] Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Shihezi 832002, China; E-Mail:;State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China; E-Mails:;Department of Microbiology, Anhui Medical University, Hefei 230032, China; E-Mails:

关键词: Kaposi’s sarcoma-associated herpesvirus (KSHV);    genotyping;    K1 gene;    Xinjiang;   

DOI  :  10.3390/v6124800

来源: mdpi

【 摘 要 】

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causal agent of all forms of Kaposi’s sarcoma (KS), including AIDS-KS, endemic KS, classic KS and iatrogenic KS. Based on Open reading frame (ORF) K1 sequence analysis, KSHV has been classified into seven major molecular subtypes (A, B, C, D, E, F and Z). The distribution of KSHV strains varies according to geography and ethnicity. Xinjiang is a unique region where the seroprevalence of KSHV is significantly higher than other parts of China. The genotyping of KSHV strains in this region has not been thoroughly studied. The present study aimed to evaluate the frequency of KSHV genotypes isolated from KS tissues in Classical KS and AIDS KS patients from Xinjiang, China. ORF-K1 of KSHV from tissue samples of 28 KS patients was amplified and sequenced. Two subtypes of KSHV were identified according to K1 genotyping. Twenty-three of them belonged to subtype A, while five of them were subtype C. More genotype A than genotype C strains were found in both Classical KS and AIDS KS. No significant difference was found in the prevalence of different genotype between Classical KS and AIDS KS.

【 授权许可】

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