Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis

Marine Drugs

Ri-Ming Huang¹  Yin-Ning Chen⁴  Ziyu Zeng⁵  Cheng-Hai Gao²  Xiangdong Su³  Yan Peng⁶ 

[1] Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; E-Mail:;Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China; E-Mail:;Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK; E-Mail:;College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; E-Mail:;School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; E-Mail:;Life Science & Technology School, Lingnan Normal University, Zhanjiang 52048, China

关键词: biological activity;    biosynthetic pathway;    marine organism;    nucleoside;    synthesis;   

DOI  :  10.3390/md12125817

来源: mdpi

【 摘 要 】

Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes. Some of these nucleosides have been obtained from a variety of marine resources. Because of the biological importance of these compounds, this review covers 68 marine originated nucleosides and their synthetic analogs published up to June 2014. The review will focus on the structures, bioactivities, synthesis and biosynthetic processes of these compounds.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.